Equipment Reference

Kion

Kion Ashwagandha (KSM-66)

Full-spectrum root extract for cortisol reduction and stress resilience

4.6

(620 community reviews)

Kion Ashwagandha uses KSM-66, the most clinically studied ashwagandha extract with 24+ published trials. 600mg daily reduces cortisol, improves stress resilience, and supports sleep quality. Ben Greenfield's brand with transparent sourcing and third-party testing.

Used by

Ben GreenfieldStress management biohackersAthletes managing cortisolSleep optimizers

Typical price: $30 – $40 USD / 60 capsules

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How It Works

Ashwagandha (Withania somnifera) is an adaptogen that modulates the HPA axis, reducing cortisol output under chronic stress. KSM-66's withanolides also support GABAergic activity and may improve thyroid function (T4 conversion) in subclinical hypothyroid individuals.

KSM-66 Extract

Full-spectrum root extract standardized to 5% withanolides. Most human trial data uses KSM-66 specifically.

Cortisol Modulation

Reduces serum cortisol by 23–30% in published trials. Supports HPA axis regulation under chronic stress.

Morning or Evening

600mg once daily with food. Morning for stress resilience; evening if sleep support is the primary goal.

What You'll Experience

First Weeks

Week 1–2

Subtle calm, reduced reactivity to stressors. Not sedating during the day.

Trial Period

Week 4–8

Published trial endpoints: cortisol reduction, improved sleep quality, and stress scores.

Long-term

Month 3+

Some tolerance reported. Consider 8–12 week cycles with 2–4 week breaks.

Benefits

Cortisol Reduction

Moderate Evidence

23–30% cortisol reduction in 60-day KSM-66 trials at 600mg/day.

Stress Resilience

Moderate Evidence

Improved perceived stress and anxiety scores in multiple RCTs.

Sleep Quality

Moderate Evidence

Secondary benefit from cortisol reduction, especially when taken in the evening.

Risks & Considerations

Thyroid Interaction

medium risk

May increase thyroid hormone levels. Monitor if on thyroid medication.

Tolerance

low risk

Some users report diminished effects after 3+ months. Cycle 8–12 weeks on, 2–4 off.

Community Reviews

Synthesized consensus from Reddit, forums, and expert sources.

Reddit r/Supplements

Mostly Positive

KSM-66 is the consensus ashwagandha extract. Kion is trusted for quality though not the cheapest option.

·KSM-66 has the most clinical trial data
·600mg daily is the validated dose
·Cycle 8–12 weeks to avoid tolerance

View source

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Last updated: 2026-07-11 · Informational only. Not medical advice.