Topic
Supplements
Nootropics, longevity compounds, vitamins, and stacks, with evidence ratings and risk profiles.
Buying Guides
Compare top products in this category before you buy.
SupplementsBest Creatine: The Buying Guide
Creatine monohydrate is the rare supplement with decades of human data for strength, and growing interest in cognition and healthy aging. You do not need hydrochloride, buffered, or a $60 tub. This buying guide picks a tested monohydrate and tells you what to ignore.
Read guide
SupplementsBest Magnesium: The Buying Guide
Magnesium is the first sleep-stack purchase that usually deserves to stay. Glycinate (bisglycinate) is the default for evenings; citrate if you also want a stool softener; threonate if you are paying extra for a cognition story. This buying guide maps forms to Amazon SKUs.
Read guide
SupplementsBest Omega-3: The Buying Guide
Omega-3 is a foundation supplement if you do not eat fatty fish twice a week. You want EPA+DHA in grams, not a 1,000mg ‘fish oil’ softgel that is mostly filler. This buying guide points at Nordic Naturals Ultimate Omega and tells you what to ignore.
Read guide
SupplementsBest Vitamin D: The Buying Guide
Vitamin D shopping is easy once you have a 25(OH)D number. D3 (cholecalciferol) beats D2. 5,000 IU is a repletion-style softgel, not a forever default. This buying guide picks NOW D3 for cheap D-only and Thorne D3/K2 when you want both in one capsule.
Read guide
SupplementsBest Protein Powder: The Buying Guide
Protein powder is a convenience layer on top of food, not a longevity molecule. Whey is the default if you tolerate dairy. Collagen is glycine and joints, not a complete muscle protein. This buying guide picks Optimum Nutrition whey and Vital Proteins collagen and tells you when to skip powder entirely.
Read guide
SupplementsBest Collagen: The Buying Guide
Collagen peptides are a glycine-rich, incomplete protein with modest skin and joint trial data. Shopping is easy: hydrolyzed peptides that dissolve, not a $70 beauty tin. This buying guide picks Vital Proteins and tells you to keep vitamin C and a complete protein in the same kitchen.
Read guide
SupplementsBest Probiotic: The Buying Guide
Most Amazon probiotic bottles are a CFU number and a mystery blend. Strain identity and published counts beat a 50-strain fireworks label. This buying guide picks Seed DS-01 as the biohacker default, tells you to eat fermented food anyway, and links the full probiotics guide for the science.
Read guide
SupplementsBest Ashwagandha: The Buying Guide
Ashwagandha shopping is extract theater. KSM-66 and Sensoril name the extract; Kion no longer lists a standalone ashwagandha SKU on getkion.com. NOW 450 mg is the Amazon bottle with a buy button. This buying guide picks NOW for checkout and tells you to stop at eight weeks if nothing changed.
Read guide
SupplementsBest Electrolytes: The Buying Guide
Electrolyte shopping is sodium theater plus flavors. Sweaty training, sauna, and low-carb diets are the usual reasons to add salt — not a $40 ‘cellular hydration’ identity. This buying guide picks LMNT as the Amazon packet and sends you to the electrolytes guide for the physiology.
Read guide
SupplementsBest NAC: The Buying Guide
NAC shopping is brand theater around one molecule. NOW 600 mg with selenium is the Amazon bulk bottle. Thorne 500 mg is the NSF-for-Sport upgrade. Oral glutathione stays a waste on this site. This buying guide picks NOW for checkout and tells you the black specks are oxidation.
Read guide
SupplementsBest CoQ10: The Buying Guide
CoQ10 shopping is form theater. NOW 100 mg ubiquinone in oil is the Amazon volume bottle. Life Extension Super Ubiquinol is the reduced-form upgrade we already list. This buying guide picks NOW for a cheap trial and sends statin users over 40 to the full CoQ10 guide before they default to the cheapest quinone.
Read guide
SupplementsBest Zinc: The Buying Guide
Zinc shopping is form and dose. Picolinate beats oxide. NOW 50 mg elemental is the cheap Amazon repletion capsule — it sits above the 40 mg/day adult upper limit, so it is not a forever daily. Thorne 15–30 mg NSF is the maintain bottle. This buying guide picks NOW for a short course and tells you to do the math with your multi.
Read guide
SupplementsBest Berberine: The Buying Guide
Berberine shopping is milligrams and GI luck. NOW 400 mg HCl with MCT is the Amazon softgel. Thorne 500 mg is the NSF upgrade. Clinical meal-time totals are often 1,000–1,500 mg/day — count capsules. This buying guide picks NOW for a cheap trial and refuses the OTC-metformin story.
Read guide
SupplementsBest Vitamin C: The Buying Guide
Vitamin C shopping is dose honesty. NOW C-1000 is the Amazon bottle already on this site. Food still covers most people. This buying guide picks NOW when you want a cheap tablet — especially next to collagen — and tells you 10 g powders and clinic IV drips are a different conversation.
Read guideGuides
SupplementsNAD+ & Longevity: The Complete Guide
NAD+ is one of the most critical molecules in human biology, essential for energy, DNA repair, and activating longevity pathways. Levels decline ~50% between ages 40–60. This guide explains what NAD+ does, whether supplementation works, NR vs NMN debate, and how to test your levels.
Read guideSupplementsCreatine Dose: 5g Daily for Muscle, Bone, and Brain
Take 5 g of creatine monohydrate every day for muscle, bone, and brain. You do not need a separate higher daily dose for bone — the bone research is still early and is studied with lifting, at ordinary doses. Some short brain studies use about 10–20 g a day, split up. That is a research protocol, not the daily dose this guide uses. Saturation from 5 g a day is the default.
Read guideSupplementsMagnesium: The Complete Guide
Up to 50% of adults may not meet optimal magnesium intake. It's involved in 300+ enzymatic reactions, sleep, muscle recovery, stress, and heart rhythm all depend on it. This guide breaks down which form to take, when, and how much.
Read guide
SupplementsBryan Johnson's Blueprint: The Complete Guide
Bryan Johnson spends ~$2M/year on his 'Don't Die' anti-aging protocol, the most measured human body in history. Blueprint includes 100+ daily supplements, precise sleep/calorie timing, plasma exchange, and relentless biomarker tracking. This guide breaks down what's evidence-based, what's experimental, and what mere mortals can actually adopt.
Read guideSupplementsOmega-3 Fatty Acids: The Complete Guide
Omega-3 fatty acids (EPA and DHA) are essential for brain structure, cardiovascular health, and inflammation control. Most Western diets are deficient. This guide covers dosing, quality testing, the Omega-3 Index, and how to choose a fish oil.
Read guideSupplementsVitamin D: The Complete Guide
Vitamin D is technically a hormone, involved in immunity, bone health, mood, and 200+ gene expressions. Deficiency affects ~40% of adults in temperate climates. This guide covers testing, dosing, K2 pairing, and sun vs supplement tradeoffs.
Read guide
SupplementsIntermittent Fasting: The Complete Guide
Intermittent fasting (IF) is one of the most practiced biohacks worldwide, popularized by Dave Asprey's Bulletproof approach and validated by decades of metabolic research. This guide covers 16:8 vs OMAD, ketosis timing, autophagy windows, and who should avoid fasting.
Read guide
SupplementsTestosterone Optimization: The Complete Guide
Testosterone optimization is one of the most searched biohacking topics, from natural lifestyle interventions to TRT clinics. Dave Asprey discusses hormonal health as core to vitality and longevity. This guide covers evidence-based natural optimization before pharmaceutical intervention.
Read guideSupplementsGlutathione: The Complete Guide
Glutathione is your body's master antioxidant, present in every cell, critical for detoxification, immune function, and mitochondrial health. Dave Asprey calls it 'the most important molecule you need to stay healthy.' This guide covers why oral glutathione fails, liposomal delivery, and NAC as a precursor.
Read guideSupplementsAshwagandha: The Complete Guide
Ashwagandha (Withania somnifera) is the most studied adaptogen in biohacking. Multiple RCTs show cortisol reduction, improved sleep, and modest strength gains. This guide compares KSM-66 and Sensoril extracts, dosing protocols, and important contraindications.
Read guide
SupplementsUrolithin A: The Complete Guide
Urolithin A is a gut microbiome metabolite that triggers mitophagy, the selective recycling of damaged mitochondria. Amazentis/Timeline's Mitopure is the first clinically validated urolithin A supplement. This guide covers the science, dosing, and who actually converts ellagic acid from food.
Read guideSupplementsCollagen Peptides: The Complete Guide
Collagen peptides are hydrolyzed collagen protein supplements supporting skin elasticity, joint comfort, and gut lining integrity. They're also a significant dietary source of glycine. This guide covers types, dosing, evidence quality, and how collagen fits a biohacking stack.
Read guide
SupplementsL-Theanine 200 mg with Caffeine (Huberman)
The focus dose is 200 mg of L-theanine with about 100 mg of caffeine, a 2:1 ratio, in the morning. Huberman’s sleep stack uses 100–200 mg of L-theanine before bed with apigenin and magnesium, without the caffeine. The same 200 mg is the amount used in the alpha-wave studies. Matcha has both compounds, but a cup is too small to match these doses.
Read guideSupplementsVitamin K2: The Complete Guide
Vitamin K2 activates proteins that direct calcium into bones and teeth while preventing arterial calcification. It's the essential partner to vitamin D3 supplementation. This guide covers MK-4 vs MK-7 forms, dosing, and why D3 without K2 may be incomplete.
Read guide
SupplementsRhodiola Rosea: The Complete Guide
Rhodiola rosea is a cold-climate adaptogen used for mental stamina, fatigue resistance, and stress buffering. Unlike sedating adaptogens, rhodiola is typically taken in the morning for calm energy. This guide covers SHR-5 and 3% rosavin extracts, dosing, and how it pairs with ashwagandha.
Read guideSupplementsBerberine: The Complete Guide
Berberine is a plant alkaloid that activates AMPK and lowers blood glucose comparably to metformin in some trials. Biohackers use it for metabolic health, CGM optimization, and longevity signaling. This guide covers 500mg dosing, GI side effects, and CGM pairing.
Read guideSupplementsNAC (N-Acetyl Cysteine): The Complete Guide
NAC is the most bioavailable precursor to glutathione, the body's master antioxidant. Used in hospitals for acetaminophen overdose, biohackers take it for liver support, respiratory health, and oxidative stress. This guide covers 600–1200mg dosing and availability considerations.
Read guideSupplementsCoQ10 (Ubiquinol): The Complete Guide
Coenzyme Q10 is essential for mitochondrial ATP production and is depleted by statin medications and aging. Biohackers supplement ubiquinol for energy, cardiovascular support, and exercise recovery. This guide compares forms, doses, and who benefits most.
Read guideSupplementsTongkat Ali: The Complete Guide
Tongkat ali (Eurycoma longifolia) is a Southeast Asian herb studied for raising free testosterone, reducing cortisol, and improving libido in men with low-normal T. This guide covers LJ100 and Physta extracts, 200–400mg dosing, and blood test monitoring.
Read guideSupplementsZinc Picolinate Dosage for Men: 15mg vs 30mg
For most men, 15 mg of elemental zinc picolinate with food is the maintain dose. Use 30 mg if you train hard, sweat a lot, or eat little meat. Do not stay above 40 mg a day for months — that is where copper runs low. A 50 mg capsule is a short repletion, not the daily plan. Thorne sells the 15 mg and 30 mg sizes; the buying notes are in [best zinc](/guides/best-zinc).
Read guideSupplementsProbiotics: Strains, Evidence, and What Actually Works
The probiotic market is a $60B mess of underdosed, poorly studied products. But specific strains with clinical trial data can meaningfully support gut health, immune function, and even mood. This guide cuts through marketing to cover evidence-backed strains, dosing in CFUs, spore vs conventional probiotics, and when testing beats guessing.
Read guideSupplementsSpermidine: Autophagy, Longevity, and Food Sources
Spermidine is a naturally occurring polyamine found in wheat germ, aged cheese, and mushrooms. It activates autophagy, the cellular cleanup process linked to longevity. Human epidemiological data shows higher dietary spermidine intake correlates with reduced cardiovascular and cancer mortality. This guide covers food sources, supplemental dosing, and how it fits into a longevity stack.
Read guide
SupplementsShilajit: Fulvic Acid, Minerals, and the Evidence
Shilajit is a tar-like resin from Himalayan rock, used in Ayurvedic medicine for centuries. Modern interest centers on fulvic acid content, mineral delivery, testosterone support, and mitochondrial function. The evidence is thin but intriguing. The bigger concern: heavy metal contamination in low-quality products. This guide covers what shilajit actually is, what research exists, dosing, and how to source clean resin.
Read guide
SupplementsAG1 & Greens Powders: Worth It or Overpriced?
AG1 (Athletic Greens) is the most marketed greens powder in biohacking — 75 ingredients in one scoop. Tim Ferriss and Huberman popularized it as nutritional insurance. This guide breaks down what's actually in greens powders, whether the $80/month price is justified, and how AG1 compares to DIY stacks and whole food.
Read guide
SupplementsFisetin & Senolytics: Clearing Zombie Cells
Senolytics are compounds that selectively kill senescent ('zombie') cells — damaged cells that stop dividing but refuse to die, secreting inflammatory signals that accelerate aging. Fisetin, a flavonoid found in strawberries, showed the strongest senolytic activity in Mayo Clinic screens. Human data is early but the biohacking community treats fisetin pulses as a tier-2 longevity intervention.
Read guide
SupplementsTaurine: The Complete Guide
Taurine is a sulfur-containing amino acid abundant in meat, seafood, and energy drinks. A 2023 Science paper linked age-related taurine decline to aging in animals and lit a longevity-community fire. This guide separates the animal data from human evidence, dosing, and who might actually benefit.
Read guide
SupplementsRapamycin: The Complete Guide
Rapamycin (sirolimus) is an mTOR inhibitor with the strongest animal lifespan data in the NIA Interventions Testing Program. Longevity clinics now discuss intermittent, physician-supervised use. This guide covers the science, what human trials actually show, risks, and why it does not belong in a self-serve supplement drawer.
Read guide
SupplementsProtein for Longevity: The Complete Guide
Protein is the most under-discussed longevity lever after sleep and training. Too little accelerates sarcopenia; the right amount supports muscle, bone, and metabolic health into older decades. This guide covers g/kg targets, meal distribution, and how protein needs change on GLP-1s and during fat loss.
Read guideSupplementsMetformin: The Complete Guide
Metformin is the most prescribed diabetes drug in the world and the most discussed off-label longevity pharmaceutical after rapamycin. It activates AMPK, lowers glucose, and shows epidemiologic links to reduced cancer and mortality in diabetics — but healthy-aging trials are still running. This guide maps the evidence without DIY dosing.
Read guide
SupplementsHydrogen Water: The Complete Guide
Hydrogen-rich water delivers dissolved molecular hydrogen (H₂), a selective antioxidant studied for exercise recovery, metabolic markers, and inflammation. Japan and Korea popularized it first; Western biohackers now debate tablets, generators, and canned H₂. This guide covers what human trials actually show and whether it belongs in your stack.
Read guideSupplementsElectrolytes & Sodium: The Complete Guide
Electrolytes are the boring infrastructure of biohacking: blood volume, nerve firing, muscle contraction, and how you feel in heat and on low-carb diets. This guide covers sodium, potassium, magnesium synergy, who needs more than RDA sodium, and when LMNT-style packets beat plain water.
Read guideSupplementsMitochondrial Health Stack: The Complete Guide
Mitochondrial biohacking is a category, not one pill. CoQ10 supports electron transport, NAD+ precursors feed sirtuins and repair pathways, urolithin A may trigger mitophagy — this guide maps how they differ, typical doses, and the exercise-first hierarchy.
Read guide
SupplementsDavid Sinclair & Longevity Science: The Complete Guide
Harvard geneticist David Sinclair changed public conversation with Lifespan (2019): aging as treatable, NAD+ and sirtuins as levers, fasting and cold as free drugs. This guide explains his research fairly, maps his personal stack, includes longevity-friendly recipes, and links Lifespan editions on Amazon.
Read guide
SupplementsWilliam Li & Eat to Beat: The Complete Guide
Physician-scientist William W. Li, MD, made angiogenesis — how the body grows and prunes blood vessels — a household idea with his TED talk and Eat to Beat Disease. This guide explains his five defense systems fairly, maps the 5×5×5 add-foods framework, includes practical recipes, and links his books on Amazon.
Read guide
SupplementsPeter Attia & Outlive: The Complete Guide
Peter Attia’s Outlive (2023) is the most useful popular longevity book of the decade: delay the Four Horsemen (atherosclerosis, cancer, neurodegeneration, metabolic disease) with exercise, lipids, sleep, and emotional health — not a supplement haul. This guide translates the book into a sequence you can actually run, and links the hardcover on Amazon.
Read guide
SupplementsResveratrol: The Complete Guide
Resveratrol is the grape-and-knotweed stilbene that made sirtuins famous. David Sinclair still discusses it; human outcome trials never matched the mouse headlines. This guide covers form (trans vs blends), dosing with fat, drug interactions, and who might still run a cheap labeled trial.
Read guide
SupplementsQuercetin: The Complete Guide
Quercetin is a flavonoid from onions and apples that shows up in senolytic stacks, seasonal-allergy protocols, and zinc-ionophore lore. Bioavailability is the product problem; bromelain pairings try to fix it. Human longevity outcomes are not established. This guide covers daily vs pulsed use and a labeled 1g option.
Read guide
SupplementsAstaxanthin: The Complete Guide
Astaxanthin is the pink carotenoid in salmon and Haematococcus algae. Human trials support modest skin and eye-fatigue benefits at 4–12mg daily; lifespan claims are marketing. Take it with fat, keep sunscreen, and treat it as a tier-2 antioxidant — not a foundation supplement.
Read guide
SupplementsGreen Tea, Matcha & EGCG: The Complete Guide
Green tea and matcha are the food form of EGCG — the catechin in countless metabolic and cancer-prevention papers. Observational and some intervention data support cardiometabolic benefits from cups, not 800mg extracts. High-dose EGCG capsules have rare liver-injury reports. Drink the leaf; be careful with pills.
Read guide
SupplementsExtra Virgin Olive Oil: The Complete Guide
Extra virgin olive oil is one of the few dietary fats with outcome-trial support when it replaces refined fats in a Mediterranean pattern. Phenols (oleocanthal, hydroxytyrosol) and oleic acid are the usual mechanisms. This guide covers how to buy, store, and cook with EVOO — and why ‘olive oil shots’ miss the point.
Read guide
SupplementsMichael Greger & How Not to Die: The Complete Guide
How Not to Die (2015) is NutritionFacts.org in hardcover: fifteen causes of death and the plant foods Greger wants on your plate. The Daily Dozen is the useful protocol. This guide separates strong diet-pattern evidence from ‘reverse disease with broccoli’ headlines and links the book plus olive oil, fiber, and matcha.
Read guide
SupplementsValter Longo & The Longevity Diet: The Complete Guide
Valter Longo’s Longevity Diet is a mostly plant, pescatarian-leaning pattern plus periodic fasting-mimicking diet (FMD) cycles from his USC lab. This guide explains the everyday plate, the protein debate with Attia, and why a 5-day kit is not a weekend water fast. Hardcover linked on Amazon.
Read guide
SupplementsFiber & Psyllium: The Complete Guide
Most longevity stacks skip the cheapest metabolic lever: dietary fiber. Psyllium husk has actual outcome data for LDL and satiety. This guide covers food sources, titration, water, drug spacing, and a labeled capsule option — not orange drink mix.
Read guideSupplementsBest Creatine: The Buying Guide
Creatine monohydrate is the rare supplement with decades of human data for strength, and growing interest in cognition and healthy aging. You do not need hydrochloride, buffered, or a $60 tub. This buying guide picks a tested monohydrate and tells you what to ignore.
Read guideSupplementsBest Magnesium: The Buying Guide
Magnesium is the first sleep-stack purchase that usually deserves to stay. Glycinate (bisglycinate) is the default for evenings; citrate if you also want a stool softener; threonate if you are paying extra for a cognition story. This buying guide maps forms to Amazon SKUs.
Read guide
SupplementsMedicinal Mushrooms: The Complete Guide
Functional mushrooms are a grocery-and-capsule category with uneven evidence. Lion’s mane has the most cognition chatter; reishi is the evening ‘calm’ mushroom; cordyceps is sold for VO₂. This guide tells you which single extracts are worth a trial and why mushroom-coffee blends usually underdose everything.
Read guide
SupplementsCurcumin & Turmeric: The Complete Guide
Curcumin is the labeled extract from turmeric with mixed human data for osteoarthritis symptoms and inflammation markers. Plain kitchen turmeric is a spice, not a trial dose. This guide covers bioavailability (fat + piperine), what the studies actually show, and a C3 Complex SKU that is not mystery powder.
Read guideSupplementsVitamin C: The Complete Guide
Vitamin C is an essential cofactor for collagen and a water-soluble antioxidant. Deficiency is rare on mixed diets; megadoses do not buy lifespan. This guide covers food vs ascorbic acid, the cold literature, and when a cheap NOW capsule is rational next to collagen powder.
Read guideSupplementsBest Omega-3: The Buying Guide
Omega-3 is a foundation supplement if you do not eat fatty fish twice a week. You want EPA+DHA in grams, not a 1,000mg ‘fish oil’ softgel that is mostly filler. This buying guide points at Nordic Naturals Ultimate Omega and tells you what to ignore.
Read guideSupplementsBest Vitamin D: The Buying Guide
Vitamin D shopping is easy once you have a 25(OH)D number. D3 (cholecalciferol) beats D2. 5,000 IU is a repletion-style softgel, not a forever default. This buying guide picks NOW D3 for cheap D-only and Thorne D3/K2 when you want both in one capsule.
Read guide
SupplementsMichael Greger & How Not to Age: The Complete Guide
How Not to Age (2023) is NutritionFacts.org aimed at hallmarks of aging: autophagy, senescent cells, AMPK, and centenarian patterns. The useful protocol is still plants, fiber, and skipping boutique serums. This guide extracts the grocery list and flags where ‘disrupt every pathway’ overreaches.
Read guide
SupplementsVitamin B12: The Complete Guide
Vitamin B12 is required for myelin, DNA synthesis, and homocysteine handling. Deficiency is a neuropathy and anemia problem — not a focus hack. This guide covers who needs a lozenge, what to test, and why NOW methyl 1,000 mcg is enough for most plant-based eaters.
Read guide
SupplementsInositol: The Complete Guide
Myo-inositol is a sugar alcohol involved in insulin signaling and some neurotransmitter pathways. Sleep-stack culture uses 1–2 g at night; PCOS clinics use grams with D-chiro. This guide separates those protocols and explains why a 500 mg NOW capsule is a trial bottle, not a fertility plan.
Read guideSupplementsBest Protein Powder: The Buying Guide
Protein powder is a convenience layer on top of food, not a longevity molecule. Whey is the default if you tolerate dairy. Collagen is glycine and joints, not a complete muscle protein. This buying guide picks Optimum Nutrition whey and Vital Proteins collagen and tells you when to skip powder entirely.
Read guideSupplementsBest Collagen: The Buying Guide
Collagen peptides are a glycine-rich, incomplete protein with modest skin and joint trial data. Shopping is easy: hydrolyzed peptides that dissolve, not a $70 beauty tin. This buying guide picks Vital Proteins and tells you to keep vitamin C and a complete protein in the same kitchen.
Read guideSupplementsBest Probiotic: The Buying Guide
Most Amazon probiotic bottles are a CFU number and a mystery blend. Strain identity and published counts beat a 50-strain fireworks label. This buying guide picks Seed DS-01 as the biohacker default, tells you to eat fermented food anyway, and links the full probiotics guide for the science.
Read guide
SupplementsMichael Greger & How Not to Diet: The Complete Guide
How Not to Diet (2019) is NutritionFacts aimed at weight: calorie density, fiber, insulin index, and a long accelerator list. The useful protocol is still plants and fewer ultra-processed calories. This guide extracts the grocery move and flags where twenty-one levers become a personality.
Read guide
SupplementsWill Bulsiewicz & Fiber Fueled: The Complete Guide
Fiber Fueled (2020) is the GI case for feeding microbes a wide range of plants. The protocol is diversity and fiber, not a forever elimination diet. This guide extracts the 30-plant idea and pairs the book with psyllium and the probiotic buying guide.
Read guide
SupplementsCitrulline: The Complete Guide
L-citrulline raises arginine and nitric oxide more reliably than oral arginine for many people. Training studies usually use grams, often as citrulline malate. This guide covers dose honesty and why NOW 750 mg capsules are a stim-free trial, not a pre-workout tub.
Read guide
SupplementsAlpha-Lipoic Acid: The Complete Guide
ALA is a mitochondrial cofactor that can recycle vitamins C and E and shows up in diabetic neuropathy and glucose conversations. Longevity evidence in healthy people is thin. This guide covers the 600 mg NOW bottle and the hypoglycemia warning if you already take diabetes drugs.
Read guide
SupplementsMethylfolate: The Complete Guide
Methylfolate (5-MTHF) is the active folate form. Most people eating greens do not need a 1,000 mcg tablet. This guide covers when Quatrefolic is rational, why high folate can mask B12 deficiency, and why a haplotype screenshot is not a protocol.
Read guideSupplementsBest Ashwagandha: The Buying Guide
Ashwagandha shopping is extract theater. KSM-66 and Sensoril name the extract; Kion no longer lists a standalone ashwagandha SKU on getkion.com. NOW 450 mg is the Amazon bottle with a buy button. This buying guide picks NOW for checkout and tells you to stop at eight weeks if nothing changed.
Read guideSupplementsBest Electrolytes: The Buying Guide
Electrolyte shopping is sodium theater plus flavors. Sweaty training, sauna, and low-carb diets are the usual reasons to add salt — not a $40 ‘cellular hydration’ identity. This buying guide picks LMNT as the Amazon packet and sends you to the electrolytes guide for the physiology.
Read guide
SupplementsTMG (Betaine): The Complete Guide
TMG (trimethylglycine, betaine anhydrous) donates methyl groups and shows up in homocysteine and liver-fat conversations. This guide covers the 1,000 mg NOW tablet and why folate and B12 are still the first methylation bottles — not a 15-supplement stack from a raw DNA file.
Read guideSupplementsBest NAC: The Buying Guide
NAC shopping is brand theater around one molecule. NOW 600 mg with selenium is the Amazon bulk bottle. Thorne 500 mg is the NSF-for-Sport upgrade. Oral glutathione stays a waste on this site. This buying guide picks NOW for checkout and tells you the black specks are oxidation.
Read guideSupplementsBest CoQ10: The Buying Guide
CoQ10 shopping is form theater. NOW 100 mg ubiquinone in oil is the Amazon volume bottle. Life Extension Super Ubiquinol is the reduced-form upgrade we already list. This buying guide picks NOW for a cheap trial and sends statin users over 40 to the full CoQ10 guide before they default to the cheapest quinone.
Read guideSupplementsBest Zinc: The Buying Guide
Zinc shopping is form and dose. Picolinate beats oxide. NOW 50 mg elemental is the cheap Amazon repletion capsule — it sits above the 40 mg/day adult upper limit, so it is not a forever daily. Thorne 15–30 mg NSF is the maintain bottle. This buying guide picks NOW for a short course and tells you to do the math with your multi.
Read guideSupplementsBest Berberine: The Buying Guide
Berberine shopping is milligrams and GI luck. NOW 400 mg HCl with MCT is the Amazon softgel. Thorne 500 mg is the NSF upgrade. Clinical meal-time totals are often 1,000–1,500 mg/day — count capsules. This buying guide picks NOW for a cheap trial and refuses the OTC-metformin story.
Read guideSupplementsBest Vitamin C: The Buying Guide
Vitamin C shopping is dose honesty. NOW C-1000 is the Amazon bottle already on this site. Food still covers most people. This buying guide picks NOW when you want a cheap tablet — especially next to collagen — and tells you 10 g powders and clinic IV drips are a different conversation.
Read guide
SupplementsSelenium: The Complete Guide
Selenium is required for glutathione enzymes and thyroid hormone conversion. The adult RDA is 55 mcg; the upper limit is 400 mcg a day from all sources. NOW’s 200 mcg L-selenomethionine is the Amazon capsule. One capsule plus a high-selenium multi plus Brazil nuts is how people overshoot. This is not a cancer protocol.
Read guide
Supplements“Natural GLP-1” Supplements: The Complete Guide
2026 marketing calls berberine, lemon flavonoids, and some collagen peptides ‘natural GLP-1.’ A few small trials show meal-time glucose or incretin shifts. None of them are a GLP-1 receptor agonist drug. They do not reproduce semaglutide’s weight-loss trials, and they are not a reason to stop a prescribed incretin. This page is the distinction.
Read guide
SupplementsAlcohol and Longevity: The Complete Guide
Alcohol is the longevity leak that survives every supplement stack. It fragments sleep, raises blood pressure and triglycerides, and increases the risk of several cancers as intake goes up. A glass of red wine is not a protocol. If you drink, fewer drinks is the change that shows up in sleep and labs. Dependence is medical care, not a biohack week.
Read guideReferenced Equipment
Equipment from our guides, with specs and trusted purchase links.
