Topic
Supplements
Nootropics, longevity compounds, vitamins, and stacks, with evidence ratings and risk profiles.
Guides
SupplementsNAD+ & Longevity: The Complete Guide
NAD+ is one of the most critical molecules in human biology, essential for energy, DNA repair, and activating longevity pathways. Levels decline ~50% between ages 40–60. This guide explains what NAD+ does, whether supplementation works, NR vs NMN debate, and how to test your levels.
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SupplementsCreatine: The Complete Guide
Creatine monohydrate is one of the few supplements with decades of human research, not just for muscle and strength, but increasingly for brain energy, recovery, and healthy aging. This guide covers dosing, loading, what form to buy, and who actually benefits.
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SupplementsMagnesium: The Complete Guide
Up to 50% of adults may not meet optimal magnesium intake. It's involved in 300+ enzymatic reactions, sleep, muscle recovery, stress, and heart rhythm all depend on it. This guide breaks down which form to take, when, and how much.
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SupplementsBryan Johnson's Blueprint: The Complete Guide
Bryan Johnson spends ~$2M/year on his 'Don't Die' anti-aging protocol, the most measured human body in history. Blueprint includes 100+ daily supplements, precise sleep/calorie timing, plasma exchange, and relentless biomarker tracking. This guide breaks down what's evidence-based, what's experimental, and what mere mortals can actually adopt.
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SupplementsOmega-3 Fatty Acids: The Complete Guide
Omega-3 fatty acids (EPA and DHA) are essential for brain structure, cardiovascular health, and inflammation control. Most Western diets are deficient. This guide covers dosing, quality testing, the Omega-3 Index, and how to choose a fish oil.
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SupplementsVitamin D: The Complete Guide
Vitamin D is technically a hormone, involved in immunity, bone health, mood, and 200+ gene expressions. Deficiency affects ~40% of adults in temperate climates. This guide covers testing, dosing, K2 pairing, and sun vs supplement tradeoffs.
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SupplementsIntermittent Fasting: The Complete Guide
Intermittent fasting (IF) is one of the most practiced biohacks worldwide, popularized by Dave Asprey's Bulletproof approach and validated by decades of metabolic research. This guide covers 16:8 vs OMAD, ketosis timing, autophagy windows, and who should avoid fasting.
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SupplementsTestosterone Optimization: The Complete Guide
Testosterone optimization is one of the most searched biohacking topics, from natural lifestyle interventions to TRT clinics. Dave Asprey discusses hormonal health as core to vitality and longevity. This guide covers evidence-based natural optimization before pharmaceutical intervention.
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SupplementsGlutathione: The Complete Guide
Glutathione is your body's master antioxidant, present in every cell, critical for detoxification, immune function, and mitochondrial health. Dave Asprey calls it 'the most important molecule you need to stay healthy.' This guide covers why oral glutathione fails, liposomal delivery, and NAC as a precursor.
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SupplementsAshwagandha: The Complete Guide
Ashwagandha (Withania somnifera) is the most studied adaptogen in biohacking. Multiple RCTs show cortisol reduction, improved sleep, and modest strength gains. This guide compares KSM-66 and Sensoril extracts, dosing protocols, and important contraindications.
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SupplementsUrolithin A: The Complete Guide
Urolithin A is a gut microbiome metabolite that triggers mitophagy, the selective recycling of damaged mitochondria. Amazentis/Timeline's Mitopure is the first clinically validated urolithin A supplement. This guide covers the science, dosing, and who actually converts ellagic acid from food.
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SupplementsCollagen Peptides: The Complete Guide
Collagen peptides are hydrolyzed collagen protein supplements supporting skin elasticity, joint comfort, and gut lining integrity. They're also a significant dietary source of glycine. This guide covers types, dosing, evidence quality, and how collagen fits a biohacking stack.
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SupplementsL-Theanine: The Complete Guide
L-theanine is an amino acid from green tea that promotes calm alertness by increasing alpha brain waves and modulating GABA, dopamine, and serotonin. Huberman includes it in his sleep stack; others pair it with caffeine for focused productivity. This guide covers both use cases.
Read guideSupplementsVitamin K2: The Complete Guide
Vitamin K2 activates proteins that direct calcium into bones and teeth while preventing arterial calcification. It's the essential partner to vitamin D3 supplementation. This guide covers MK-4 vs MK-7 forms, dosing, and why D3 without K2 may be incomplete.
Read guideSupplementsRhodiola Rosea: The Complete Guide
Rhodiola rosea is a cold-climate adaptogen used for mental stamina, fatigue resistance, and stress buffering. Unlike sedating adaptogens, rhodiola is typically taken in the morning for calm energy. This guide covers SHR-5 and 3% rosavin extracts, dosing, and how it pairs with ashwagandha.
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SupplementsBerberine: The Complete Guide
Berberine is a plant alkaloid that activates AMPK and lowers blood glucose comparably to metformin in some trials. Biohackers use it for metabolic health, CGM optimization, and longevity signaling. This guide covers 500mg dosing, GI side effects, and CGM pairing.
Read guideSupplementsNAC (N-Acetyl Cysteine): The Complete Guide
NAC is the most bioavailable precursor to glutathione, the body's master antioxidant. Used in hospitals for acetaminophen overdose, biohackers take it for liver support, respiratory health, and oxidative stress. This guide covers 600–1200mg dosing and availability considerations.
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SupplementsCoQ10 (Ubiquinol): The Complete Guide
Coenzyme Q10 is essential for mitochondrial ATP production and is depleted by statin medications and aging. Biohackers supplement ubiquinol for energy, cardiovascular support, and exercise recovery. This guide compares forms, doses, and who benefits most.
Read guideSupplementsTongkat Ali: The Complete Guide
Tongkat ali (Eurycoma longifolia) is a Southeast Asian herb studied for raising free testosterone, reducing cortisol, and improving libido in men with low-normal T. This guide covers LJ100 and Physta extracts, 200–400mg dosing, and blood test monitoring.
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SupplementsZinc: The Complete Supplement Guide
Zinc is an essential trace mineral involved in 300+ enzymatic reactions, immune function, testosterone production, wound healing, and sleep regulation. Mild deficiency is common in athletes, vegetarians, and those with high sweat losses. This guide covers forms, dosing, copper balance, and who actually needs to supplement.
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SupplementsProbiotics: Strains, Evidence, and What Actually Works
The probiotic market is a $60B mess of underdosed, poorly studied products. But specific strains with clinical trial data can meaningfully support gut health, immune function, and even mood. This guide cuts through marketing to cover evidence-backed strains, dosing in CFUs, spore vs conventional probiotics, and when testing beats guessing.
Read guideSupplementsSpermidine: Autophagy, Longevity, and Food Sources
Spermidine is a naturally occurring polyamine found in wheat germ, aged cheese, and mushrooms. It activates autophagy, the cellular cleanup process linked to longevity. Human epidemiological data shows higher dietary spermidine intake correlates with reduced cardiovascular and cancer mortality. This guide covers food sources, supplemental dosing, and how it fits into a longevity stack.
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SupplementsShilajit: Fulvic Acid, Minerals, and the Evidence
Shilajit is a tar-like resin from Himalayan rock, used in Ayurvedic medicine for centuries. Modern interest centers on fulvic acid content, mineral delivery, testosterone support, and mitochondrial function. The evidence is thin but intriguing. The bigger concern: heavy metal contamination in low-quality products. This guide covers what shilajit actually is, what research exists, dosing, and how to source clean resin.
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SupplementsAG1 & Greens Powders: Worth It or Overpriced?
AG1 (Athletic Greens) is the most marketed greens powder in biohacking — 75 ingredients in one scoop. Tim Ferriss and Huberman popularized it as nutritional insurance. This guide breaks down what's actually in greens powders, whether the $80/month price is justified, and how AG1 compares to DIY stacks and whole food.
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SupplementsFisetin & Senolytics: Clearing Zombie Cells
Senolytics are compounds that selectively kill senescent ('zombie') cells — damaged cells that stop dividing but refuse to die, secreting inflammatory signals that accelerate aging. Fisetin, a flavonoid found in strawberries, showed the strongest senolytic activity in Mayo Clinic screens. Human data is early but the biohacking community treats fisetin pulses as a tier-2 longevity intervention.
Read guideSupplementsTaurine: The Complete Guide
Taurine is a sulfur-containing amino acid abundant in meat, seafood, and energy drinks. A 2023 Science paper linked age-related taurine decline to aging in animals and lit a longevity-community fire. This guide separates the animal data from human evidence, dosing, and who might actually benefit.
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SupplementsRapamycin: The Complete Guide
Rapamycin (sirolimus) is an mTOR inhibitor with the strongest animal lifespan data in the NIA Interventions Testing Program. Longevity clinics now discuss intermittent, physician-supervised use. This guide covers the science, what human trials actually show, risks, and why it does not belong in a self-serve supplement drawer.
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SupplementsProtein for Longevity: The Complete Guide
Protein is the most under-discussed longevity lever after sleep and training. Too little accelerates sarcopenia; the right amount supports muscle, bone, and metabolic health into older decades. This guide covers g/kg targets, meal distribution, and how protein needs change on GLP-1s and during fat loss.
Read guideSupplementsMetformin: The Complete Guide
Metformin is the most prescribed diabetes drug in the world and the most discussed off-label longevity pharmaceutical after rapamycin. It activates AMPK, lowers glucose, and shows epidemiologic links to reduced cancer and mortality in diabetics — but healthy-aging trials are still running. This guide maps the evidence without DIY dosing.
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SupplementsHydrogen Water: The Complete Guide
Hydrogen-rich water delivers dissolved molecular hydrogen (H₂), a selective antioxidant studied for exercise recovery, metabolic markers, and inflammation. Japan and Korea popularized it first; Western biohackers now debate tablets, generators, and canned H₂. This guide covers what human trials actually show and whether it belongs in your stack.
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SupplementsElectrolytes & Sodium: The Complete Guide
Electrolytes are the boring infrastructure of biohacking: blood volume, nerve firing, muscle contraction, and how you feel in heat and on low-carb diets. This guide covers sodium, potassium, magnesium synergy, who needs more than RDA sodium, and when LMNT-style packets beat plain water.
Read guideSupplementsMitochondrial Health Stack: The Complete Guide
Mitochondrial biohacking is a category, not one pill. CoQ10 supports electron transport, NAD+ precursors feed sirtuins and repair pathways, urolithin A may trigger mitophagy — this guide maps how they differ, typical doses, and the exercise-first hierarchy.
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SupplementsDavid Sinclair & Longevity Science: The Complete Guide
Harvard geneticist David Sinclair changed public conversation with Lifespan (2019): aging as treatable, NAD+ and sirtuins as levers, fasting and cold as free drugs. This guide explains his research fairly, maps his personal stack, includes longevity-friendly recipes, and links Lifespan editions on Amazon.
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SupplementsWilliam Li & Eat to Beat: The Complete Guide
Physician-scientist William W. Li, MD, made angiogenesis — how the body grows and prunes blood vessels — a household idea with his TED talk and Eat to Beat Disease. This guide explains his five defense systems fairly, maps the 5×5×5 add-foods framework, includes practical recipes, and links his books on Amazon.
Read guideReferenced Equipment
Equipment from our guides, with specs and trusted purchase links.
