Longevindex
9 min readDeep diveUpdated 2026-09-22

Citrulline: The Complete Guide

L-citrulline vs citrulline malate, gram doses, and why one 750 mg capsule is not a protocol

L-citrulline raises arginine and nitric oxide more reliably than oral arginine for many people. Training studies usually use grams, often as citrulline malate. This guide covers dose honesty and why NOW 750 mg capsules are a stim-free trial, not a pre-workout tub.

Health Disclaimer

This content is for general informational and educational purposes only. It is not medical advice, diagnosis, or treatment. Consult a qualified healthcare provider before starting any supplement, peptide, or health protocol. Read our full health disclaimer.

Frequency

On training days, 30–60 minutes before

Duration

As long as you notice a reason to stay

Level

Beginner

Citrulline: The Complete Guide

Key Takeaways

  • 1Performance literature is grams — count capsules or buy powder if you stay on it
  • 2Citrulline is optional; creatine and protein are not
  • 3No caffeine in the NOW SKU — keep stims separate
  • 4Ask if you are on blood-pressure medication

Who this is for

  • ·People staring at a 20-ingredient pre-workout
  • ·Night trainers who do not want more caffeine
  • ·Anyone who already hits creatine and protein
Advocated by
Lifters who hate flavored pre-workoutsHuberman-adjacent trainers

L-Citrulline vs Malate

Moderate Evidence

Malate is the gym-bro form in most powders (often 2:1 citrulline to malate). Plain L-citrulline is what NOW sells. Either can work; the dose of actual citrulline is what matters.

Dose

Moderate Evidence

Studies that show a pump or a small performance bump are usually 3–8 g citrulline-equivalent. One 750 mg capsule is a taste, not a protocol.

As an Amazon Associate, Reo Tuku Iho Limited earns from qualifying purchases through Amazon links on this site. Full disclosure

For educational purposes only. Not medical advice. Read our health disclaimer.

Sources

Key references cited in this guide. Links open the original publication or abstract.

  1. Citrulline and exercise performance — review contextJ Strength Cond Res, 2012

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Last updated: 2026-09-22 · For informational purposes only. Not medical advice. Consult a healthcare provider before starting any new health protocol. Health disclaimer.