Equipment Reference
NOW Foods
NOW Foods TMG 1,000 mg
NOW Foods TMG 1,000mg review — betaine anhydrous methyl-donor tablets for lowering homocysteine and pairing with NMN or NR NAD+ precursors.
Betaine anhydrous tablets — a methylation / homocysteine adjunct, not a longevity personality
NOW’s 1,000 mg TMG (trimethylglycine, betaine anhydrous) is the cheap Amazon methylation tablet. The interesting literature is homocysteine and liver fat context — not a reason to build a 15-supplement ‘methylation stack’ from a genealogy PDF. Pair with methylfolate, methyl B12, and an actual lab. See the TMG guide.
Health Disclaimer
This content is for general informational and educational purposes only. It is not medical advice, diagnosis, or treatment. Consult a qualified healthcare provider before starting any supplement, peptide, or health protocol. Read our full health disclaimer.
Typical price: $12 – $20 USD / 100 tablets
How It Works
Betaine is a methyl donor. Homocysteine papers are the least-hand-wavy use. Longevity claims are extrapolation from methylation slogans.
1,000 mg Tablet
Label doses vary; many people start at one tablet with food. More is not a better genotype.
Donates Methyls
Helps remethylate homocysteine toward methionine in the betaine pathway. Labs beat a 23andMe screenshot.
Not SAMe Theater
TMG is not a mood drug and not a replacement for sleep.
What You'll Experience
If Homocysteine Was High
Weeks to a retestThat is a clinician + B12/folate conversation. TMG is optional adjunct.
If You Were Fine
8 weeksYou will feel nothing. Stop.
Benefits
Cheap and Labeled
Moderate Evidence1,000 mg is a real number, not a pixie-dust blend.
Pairs With Folate/B12
Moderate EvidenceThose two are still the first methylation bottles on this site.
Risks & Considerations
GI and Body Odor
low riskHigh-dose betaine can smell and cramp. Drop the dose.
Not a Diagnosis
high riskA high homocysteine needs a workup — B12, folate, kidneys — not only Amazon.
Community Reviews
Synthesized consensus from Reddit, forums, and expert sources.
Lab-driven users are the most positive. Longevity stackers are quieter. Smart comments mention folate and B12 first.
- ·1,000 mg
- ·Homocysteine
- ·Not a stack
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Learn More: Full Guides
SupplementsMethylfolate (5-MTHF) Guide: Daily Dose, MTHFR & Who Should Avoid It
Methylfolate (5-MTHF) is the biologically active form of folate (vitamin B9). How much L-methylfolate should you take daily, when should you take it, and who should not take methylfolate? Typical maintenance dosing is 400–1,000 mcg taken in the morning with breakfast alongside active Vitamin B12 ([NOW Methyl B-12](/equipment/now-foods-methyl-b12)). Never take high-dose folate with an uncorrected B12 deficiency, seizure medications without physician oversight, or methotrexate.
Read guideSupplementsWhat Is TMG (Betaine)? Homocysteine, NMN, and Dose
TMG (trimethylglycine, betaine anhydrous) donates methyl groups and shows up in homocysteine and liver-fat conversations. This guide covers the 1,000 mg NOW tablet and why folate and B12 are still the first methylation bottles — not a 15-supplement stack from a raw DNA file.
Read guide
SupplementsNAD+ and Longevity: NR vs NMN, Tru Niagen Dose, and Testing
NAD+ is one of the most critical molecules in human biology, essential for energy, DNA repair, and activating longevity pathways. Levels decline ~50% between ages 40–60. This guide explains what NAD+ does, whether supplementation works, NR vs NMN debate, and how to test your levels.
Read guideLast updated: 2026-09-22 · Informational only. Not medical advice. Health disclaimer.