TMG (Betaine): The Complete Guide
Homocysteine, methyl donors, and why a genealogy PDF is not a protocol
TMG (trimethylglycine, betaine anhydrous) donates methyl groups and shows up in homocysteine and liver-fat conversations. This guide covers the 1,000 mg NOW tablet and why folate and B12 are still the first methylation bottles — not a 15-supplement stack from a raw DNA file.
Health Disclaimer
This content is for general informational and educational purposes only. It is not medical advice, diagnosis, or treatment. Consult a qualified healthcare provider before starting any supplement, peptide, or health protocol. Read our full health disclaimer.
Frequency
Daily with food if supplementing
Duration
Until a retest — then decide
Level
Beginner
Key Takeaways
- 1Get a homocysteine (and B12/folate) number before you build a methylation identity
- 2NOW 1,000 mg is the Amazon SKU; more is not a better genotype
- 3Methylfolate and methyl B12 remain first-line on this site
- 4SAMe theater and 12-gene protocols are a skip
Who this is for
- ·People with a lab result and a clinician
- ·Readers comparing TMG vs another methylation bottle
- ·Anyone tempted by a 23andMe shopping list
What It Is
Moderate EvidenceBetaine remethylates homocysteine toward methionine on a pathway that is not the folate cycle. That is the least-hand-wavy sentence in the category.
Labs First
Moderate EvidenceHigh homocysteine can be B12, folate, kidneys, or thyroid. TMG is optional adjunct. See methylfolate and vitamin B12.
Skip
Moderate EvidenceA 15-bottle ‘MTHFR protocol’ with no bloodwork. Treating TMG as a mood drug. Doubling the tablet because a tweet said 3 g.
As an Amazon Associate, Reo Tuku Iho Limited earns from qualifying purchases through Amazon links on this site. Full disclosure
For educational purposes only. Not medical advice. Read our health disclaimer.
Sources
Key references cited in this guide. Links open the original publication or abstract.
- Betaine and homocysteine — clinical contextAm J Clin Nutr, 2005
Continue Reading
SupplementsMethylfolate: The Complete Guide
Methylfolate (5-MTHF) is the active folate form. Most people eating greens do not need a 1,000 mcg tablet. This guide covers when Quatrefolic is rational, why high folate can mask B12 deficiency, and why a haplotype screenshot is not a protocol.
Read guideSupplementsVitamin B12: The Complete Guide
Vitamin B12 is required for myelin, DNA synthesis, and homocysteine handling. Deficiency is a neuropathy and anemia problem — not a focus hack. This guide covers who needs a lozenge, what to test, and why NOW methyl 1,000 mcg is enough for most plant-based eaters.
Read guide
Diagnostics & TestingBlood Panel Testing: The Complete Guide
Annual bloodwork is the foundation of data-driven biohacking. Peter Attia's framework prioritizes ApoB, insulin, HbA1c, and inflammatory markers over standard lipid panels. This guide covers what to test, how often, where to order, and how to interpret results.
Read guide
SupplementsDavid Sinclair & Longevity Science: The Complete Guide
Harvard geneticist David Sinclair changed public conversation with Lifespan (2019): aging as treatable, NAD+ and sirtuins as levers, fasting and cold as free drugs. This guide explains his research fairly, maps his personal stack, includes longevity-friendly recipes, and links Lifespan editions on Amazon.
Read guide
SupplementsAlpha-Lipoic Acid: The Complete Guide
ALA is a mitochondrial cofactor that can recycle vitamins C and E and shows up in diabetic neuropathy and glucose conversations. Longevity evidence in healthy people is thin. This guide covers the 600 mg NOW bottle and the hypoglycemia warning if you already take diabetes drugs.
Read guideLast updated: 2026-09-22 · For informational purposes only. Not medical advice. Consult a healthcare provider before starting any new health protocol. Health disclaimer.