What Is TMG (Betaine)? Homocysteine, NMN, and Dose
TMG (trimethylglycine / betaine) guide: homocysteine reduction, methyl-group pairing with NMN/NR (NAD+ boosters), ergogenic dosing, and NOW TMG on Amazon.
Homocysteine, methyl donors, and why a genealogy PDF is not a protocol
TMG (trimethylglycine, betaine anhydrous) donates methyl groups and shows up in homocysteine and liver-fat conversations. This guide covers the 1,000 mg NOW tablet and why folate and B12 are still the first methylation bottles — not a 15-supplement stack from a raw DNA file.
Health Disclaimer
This content is for general informational and educational purposes only. It is not medical advice, diagnosis, or treatment. Consult a qualified healthcare provider before starting any supplement, peptide, or health protocol. Read our full health disclaimer.
Frequency
Daily with food if supplementing
Duration
Until a retest — then decide
Level
Beginner
Key Takeaways
- 1Get a homocysteine (and B12/folate) number before you build a methylation identity
- 2NOW 1,000 mg is the Amazon SKU; more is not a better genotype
- 3Methylfolate and methyl B12 remain first-line on this site
- 4SAMe theater and 12-gene protocols are a skip
Who this is for
- ·People with a lab result and a clinician
- ·Readers comparing TMG vs another methylation bottle
- ·Anyone tempted by a 23andMe shopping list
What It Is
Moderate EvidenceBetaine remethylates homocysteine toward methionine on a pathway that is not the folate cycle. That is the least-hand-wavy sentence in the category.
Labs First
Moderate EvidenceHigh homocysteine can be B12, folate, kidneys, or thyroid. TMG is optional adjunct. See methylfolate and vitamin B12.
Skip
Moderate EvidenceA 15-bottle ‘MTHFR protocol’ with no bloodwork. Treating TMG as a mood drug. Doubling the tablet because a tweet said 3 g.
As an Amazon Associate, Reo Tuku Iho Limited earns from qualifying purchases through Amazon links on this site. Full disclosure
For educational purposes only. Not medical advice. Read our health disclaimer.
Sources
Key references cited in this guide. Links open the original publication or abstract.
- Betaine and homocysteine — clinical contextAm J Clin Nutr, 2005
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Read guideLast updated: 2026-09-22 · For informational purposes only. Not medical advice. Consult a healthcare provider before starting any new health protocol. Health disclaimer.